Huanbin Xu, PhD
Associate Professor of Pathology and Laboratory Medicine
Education & Affiliations
Research
Huanbin Xu, PhD, is an associate professor with tenure in the Department of Pathology and Laboratory Medicine at the Tulane University School of Medicine. Dr. Xu has been active and productive in the fields of immunology and infectious diseases after completion of specialized postdoctoral training at Harvard University Medical School and Tulane University Medical School.
His major scopes of research have involved germinal center responses, innate immunity, and viral reservoir establishment and how the epigenetic regulation contributes to these cell subsets and events in HIV infection. Currently, his focus is on 1) deciphering the impacts of pediatric HIV infection and early treatment on immune development and function in infants; 2) exploring curative strategies in relation to early interventions, HIV latency reactivation and HIV genome ablation by gene editing, and by in vivo delivery systems; 3) identifying HIV reservoir seeding and eradication; and 4) trained innate immunity in pediatric infectious diseases.
As an independent Principal Investigator, Dr. Xu has demonstrated his commitment to collaboration on several topics with extramural funding. Dr. Xu has published on several key topics in immunity to HIV/SIV infection and cure strategies, which have been featured in the Journal of Immunology, Mucosal Immunology and EBioMedicine. In addition, Dr. Xu is also reviewer for several NIH study sections, AD hoc reviewer for journals, editorial board of Scientific Reports and Frontiers.
Professional Awards
Award from Carol Lavin Bernick Foundation in LB Grant program, 2020
Outstanding Achievement and Commitment to Excellence In Total Competitive Research funding, Tulane University School of Medicine, 2015
Contributions
Wang X, Vincent E, Siddiqui S, Turnbull K, Lu H, Blair R, Wu X, Watkins M, Ziani W, Shao J, Doyle-Meyers LA, Russell-Lodrigue KE, Bohm RP, Veazey RS, Xu H. Early treatment regimens achieve sustained virologic remission in infant macaques infected with SIV at birth. Nat Commun. 2022. 13 (1): 4823. PMID: 35973985
Ziani W, Shao J, Wang X, Russell-Lodrigue K, Liu Y, Montaner L, Veazey R and Xu H. Increased proviral DNA in circulating cells correlates with plasma viral rebound in simian immunodeficiency virus-infected rhesus macaques after antiretroviral therapy interruption. J Virol. 2021. DOI:10.1128/JVI.02064-20. PMID: 33408173
Xu H, Ziani, Shao JS, Doyle-Meyers LA, Russell-Lodrigue KE, Ratterree M, Veazey RS and Wang X. Impaired development and expansion of germinal center follicular T helper cells in SIV-infected neonatal macaques. J Immunol. 2018. 201(7): 1994-2003. PMID: 30104244
Xu H, Wang X, Malam N, Aye PP, Alvarez X, Lackner AA and Veazey RS. Persistent SIV infection drives differentiation, aberrant accumulation, and latent infection of germinal center follicular T helper cells. J Virol. 2015. PMID: 26608323
Xu H, Wang X, Liu DX, Rasmussen T, Lackner AA, Veazey RS. IL-17-producing innate lymphoid cells are restricted to mucosal tissues and are depleted in SIV-infected macaques. Mucosal Immunol. 2012. 5(6): 658-669. PMID: 22669579
