Pyone Pyone Aye, PhD
Associate Professor of Medicine
Education & Affiliations
Research
Research Interests
- HIV/ SIV vaccine
- HIV/ SIV pathogenesis and immunology
- Research administration and management
Research Programs
Simian Vaccine Evaluation Unit
Pre-clinical trial of HIV vaccine on behalf of Preclinical Research and Development Branch, Vaccine Research Program, National Institute of Allergy and Infectious Diseases
Collaborative Research
The Unit of Collaborative Research facilitates a critical part of the central mission of the NPRC program by providing access to nonhuman primate resources to affiliate scientists. The unit provides assistance to affiliate scientists who wish to use the resources of the TNPRC, but do not have an established collaboration with TNPRC core scientists. The unit also assists core investigators who have established collaborations with affiliate scientists to assure that access to resources is efficient.
Contributions
Phung I, Rodrigues KA, Marina-Zárate E, Maiorino L, Pahar B, Lee WH, Melo M, Kaur A, Allers C, Fahlberg M, Grasperge BF, Dufour JP, Schiro F, Aye PP, Lopez PG, Torres JL, Ozorowski G, Eskandarzadeh S, Kubitz M, Georgeson E, Groschel B, Nedellec R, Bick M, Kaczmarek Michaels K, Gao H, Shen X, Carnathan DG, Silvestri G, Montefiori DC, Ward AB, Hangartner L, Veazey RS, Burton DR, Schief WR, Irvine DJ, Crotty S. A combined adjuvant approach primes robust germinal center responses and humoral immunity in non-human primates. Nat Commun. 2023 Nov 4;14(1):7107. doi: 10.1038/s41467-023-42923-x. PubMed PMID: 37925510; PubMed Central PMCID: PMC10625619.
Lee JH, Sutton HJ, Cottrell CA, Phung I, Ozorowski G, Sewall LM, Nedellec R, Nakao C, Silva M, Richey ST, Torres JL, Lee WH, Georgeson E, Kubitz M, Hodges S, Mullen TM, Adachi Y, Cirelli KM, Kaur A, Allers C, Fahlberg M, Grasperge BF, Dufour JP, Schiro F, Aye PP, Kalyuzhniy O, Liguori A, Carnathan DG, Silvestri G, Shen X, Montefiori DC, Veazey RS, Ward AB, Hangartner L, Burton DR, Irvine DJ, Schief WR, Crotty S. Long-primed germinal centres with enduring affinity maturation and clonal migration. Nature. 2022 Sep;609(7929):998-1004. doi: 10.1038/s41586-022-05216-9. Epub 2022 Sep 21. PubMed PMID: 36131022; PubMed Central PMCID: PMC9491273.
Rahman MA, Becerra-Flores M, Patskovsky Y, Silva de Castro I, Bissa M, Basu S, Shen X, Williams LD, Sarkis S, N'guessan KF, LaBranche C, Tomaras GD, Aye PP, Veazey R, Paquin-Proulx D, Rao M, Franchini G, Cardozo T. Cholera toxin B scaffolded, focused SIV V2 epitope elicits antibodies that influence the risk of SIV(mac251) acquisition in macaques. Front Immunol. 2023;14:1139402. doi: 10.3389/fimmu.2023.1139402. eCollection 2023. PubMed PMID: 37153584; PubMed Central PMCID: PMC10160393.
McKenna P, Hoffmann C, Minkah N, Aye PP, Lackner A, Liu Z, Lozupone CA, Hamady M, Knight R, Bushman FD. The macaque gut microbiome in health, lentiviral infection, and chronic enterocolitis. PLoS pathogens. 2008; 4(2):e20. PMID:18248093, PMCID: PMC2222957
