Pyone Pyone Aye, PhD

Associate Professor of Medicine

Assistant Director for Collaborative Research
(985) 871-6486
18703 Three Rivers Road, Covington LA 70433
Pyone Pyone Aye

Education & Affiliations

BVS, Institute of Veterinary Medicine and Husbandry, Yangon, Myanmar
MS, University of Hawaii at Manoa
PhD, Ohio State University



Research Interests

  • HIV/ SIV vaccine

  • HIV/ SIV pathogenesis and immunology

  • Research administration and management


Research Programs

Simian Vaccine Evaluation Unit

Pre-clinical trial of HIV vaccine on behalf of Preclinical Research and Development Branch, Vaccine Research Program, National Institute of Allergy and Infectious Diseases

Collaborative Research

The Unit of Collaborative Research facilitates a critical part of the central mission of the NPRC program by providing access to nonhuman primate resources to affiliate scientists. The unit provides assistance to affiliate scientists who wish to use the resources of the TNPRC, but do not have an established collaboration with TNPRC core scientists. The unit also assists core investigators who have established collaborations with affiliate scientists to assure that access to resources is efficient.


Lee JH, Sutton HJ, Cottrell CA, Phung I, Ozorowski G, Sewall LM, Nedellec R, Nakao C, Silva M, Richey ST, Torres JL, Lee WH, Georgeson E, Kubitz M, Hodges S, Mullen TM, Adachi Y, Cirelli KM, Kaur A, Allers C, Fahlberg M, Grasperge BF, Dufour JP, Schiro F, Aye PP, Kalyuzhniy O, Liguori A, Carnathan DG, Silvestri G, Shen X, Montefiori DC, Veazey RS, Ward AB, Hangartner L, Burton DR, Irvine DJ, Schief WR, Crotty S. Long-primed germinal centres with enduring affinity maturation and clonal migration. Nature. 2022 Sep;609(7929):998-1004. doi: 10.1038/s41586-022-05216-9. Epub 2022 Sep 21. PubMed PMID: 36131022; PubMed Central PMCID: PMC9491273.
Arunachalam PS, Walls AC, Golden N, Atyeo C, Fischinger S, Li C, Aye P, Navarro MJ, Lai L, Edara VV, Röltgen K, Rogers K, Shirreff L, Ferrell DE, Wrenn S, Pettie D, Kraft JC, Miranda MC, Kepl E, Sydeman C, Brunette N, Murphy M, Fiala B, Carter L, White AG, Trisal M, Hsieh CL, Russell-Lodrigue K, Monjure C, Dufour J, Spencer S, Doyle-Meyers L, Bohm RP, Maness NJ, Roy C, Plante JA, Plante KS, Zhu A, Gorman MJ, Shin S, Shen X, Fontenot J, Gupta S, O'Hagan DT, Van Der Most R, Rappuoli R, Coffman RL, Novack D, McLellan JS, Subramaniam S, Montefiori D, Boyd SD, Flynn JL, Alter G, Villinger F, Kleanthous H, Rappaport J, Suthar MS, King NP, Veesler D, Pulendran B. Adjuvanting a subunit COVID-19 vaccine to induce protective immunity. Nature. 2021 Jun;594(7862):253-258. doi: 10.1038/s41586-021-03530-2. Epub 2021 Apr 19. PMID: 33873199.

Lawrence SP, Elser SE, Torben W, Blair RV, Pahar B, Aye PP, Schiro F, Szeltner D, Doyle-Meyers LA, Haggarty BS, Jordan APO, Romano J, Leslie GJ, Alvarez X, O'Connor DH, Wiseman RW, Fennessey CM, Li Y, Piatak M Jr, Lifson JD, LaBranche CC, Lackner AA, Keele BF, Maness NJ, Marsh M, Hoxie JA. A cellular trafficking signal in the SIV envelope protein cytoplasmic domain is strongly selected for in pathogenic infection. PLoS Pathog. 2022 Jun;18(6):e1010507. doi: 10.1371/journal.ppat.1010507. eCollection 2022 Jun. PubMed PMID: 35714165; PubMed Central PMCID: PMC9275724.
McKenna P, Hoffmann C, Minkah N, Aye PP, Lackner A, Liu Z, Lozupone CA, Hamady M, Knight R, Bushman FD. The macaque gut microbiome in health, lentiviral infection, and chronic enterocolitis. PLoS pathogens. 2008; 4(2):e20. PMID:18248093, PMCID: PMC2222957

View Dr. Aye's publications on PubMed.