Simian Vaccine Evaluation Unit
Pre-clinical trial of HIV vaccine on behalf of Preclinical Research and Development Branch, Vaccine Research Program, National Institute of Allergy and Infectious Diseases
To facilitate a critical part of the central mission of the NPRC program by providing access to nonhuman primate resources to affiliate scientists. The unit provides assistance to affiliate scientists who wish to use the resources of the TNPRC, but do not have an established collaboration with TNPRC core scientists. The unit also assists core investigators who have established collaborations with affiliate scientists to assure that access to resources is efficient.
McKenna P, Hoffmann C, Minkah N, Aye PP, Lackner A, Liu Z, Lozupone CA, Hamady M, Knight R, Bushman FD. The macaque gut microbiome in health, lentiviral infection, and chronic enterocolitis. PLoS pathogens. 2008; 4(2):e20. PMID:18248093, PMCID: PMC2222957
Magnani DM, Rogers TF, Maness NJ, Grubaugh ND, Beutler N, Bailey VK, Gonzalez-Nieto L, Gutman MJ, Pedreño-Lopez N, Kwal JM, Ricciardi MJ, Myers TA, Julander JG, Bohm RP, Gilbert MH, Schiro F, Aye PP, Blair RV, Martins MA, Falkenstein KP, Kaur A, Curry CL, et al. Fetal demise and failed antibody therapy during Zika virus infection of pregnant macaques. Nat Commun. 2018 Apr 24;9(1):1624. doi: 10.1038/s41467-018-04056-4. PMCID: PMC5915455
Himes JE, Goswami R, Mangan RJ, Kumar A, Jeffries TL Jr, Eudailey JA, Heimsath H, Nguyen QN, Pollara J, LaBranche C, Chen M, Vandergrift NA, Peacock JW, Schiro F, Midkiff C, Ferrari G, Montefiori DC, Hernandez XA, Aye PP, Permar SR. Polyclonal HIV envelope-specific breast milk antibodies limit founder SHIV acquisition and cell-associated virus loads in infant rhesus monkeys. Mucosal Immunol. 2018 Nov;11(6):1716-1726. doi: 10.1038/s41385-018-0067-7. PMID: 30115994
Dowling DJ, van Haren SD, Scheid A, Bergelson I, Kim D, Mancuso CJ, Foppen W, Ozonoff A, Fresh L, Theriot TB, Lackner AA, Fichorova RN, Smirnov D, Vasilakos JP, Beaurline JM, Tomai MA, Midkiff CC, Alvarez X, Blanchard JL, Gilbert MH, Aye PP, Levy O. TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth. JCI insight. 2017; 2(6):e91020. PMCID: PMC5360187
Mohan M, Kaushal D, Aye PP, Alvarez X, Veazey RS, Lackner AA. Focused examination of the intestinal lamina propria yields greater molecular insight into mechanisms underlying SIV induced immune dysfunction. PLoS One. 2012;7(4):e34561. PMCID: PMC3325268
View Dr. Aye's publications on PubMed.