My research focuses on elucidating the role of metabolism in HIV-1 biogenesis and survival in latent CNS reservoirs, and the effects of HIV-1 induced neuro-inflammatory cytokines and small extracellular vesicles released from HIV-1 infected macrophage and microglia on the regulation of astrocyte glutamate transporter, EAAT2 and neurodegeneration. I am also interested in assessing the impact of substance of abuse such as opiate and cocaine on the cross-talk between cellular metabolism and epigenetics in HIV-1 biogenesis in macrophage and microglia, and astrocyte EAAT2 and non-coding RNA regulation.
Cross-talk between metabolism and epigenetics. Role of extracellular vesicles in NeuroHIV. Regulation of glutamate transporters and non-coding RNA.
Role of exosomes from HIV-1 infected cells in neurodegeneration. 20th Scientific Conference of Society on Neuroimmune Pharmacology, March 26-29, 2014, New Orleans, LA.
Macrophage OXPHOS regulation by HIV-1 Vpr and cocaine. 14th International Symposium on Neurovirology, Oct 25-28, 2016, Toronto, Ontario, Canada.
EVs released from Tat-treated microglia inhibit EAAT2 expression in astrocytes. Third Annual Extracellular Vesicles and Infections meeting" May 31- June 1, 2019, Bolger Center, Potomac, MD.
View Dr. Datta's publications on PubMed.
