Prasun K. Datta, PhD
Associate Professor of Microbiology and Immunology
Education & Affiliations
Research
My research focuses on elucidating the role of metabolism in HIV-1 biogenesis and survival in latent CNS reservoirs, and the effects of HIV-1 induced neuro-inflammatory cytokines and small extracellular vesicles released from HIV-1 infected macrophage and microglia on the regulation of astrocyte glutamate transporter, EAAT2 and neurodegeneration. I am also interested in assessing the impact of substance of abuse such as opiate and cocaine on the cross-talk between cellular metabolism and epigenetics in HIV-1 biogenesis in macrophage and microglia, nd astrocyte EAAT2 and non-coding RNA regulation.
Research Programs
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Cross-talk between metabolism and epigenetics
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Role of extracellular vesicles in NeuroHIV
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Regulation of glutamate transporters and non-coding RNA.
Key Presentations
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Role of exosomes from HIV-1 infected cells in neurodegeneration. 20th Scientific Conference of Society on Neuroimmune Pharmacology, March 26-29, 2014, New Orleans, LA.
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Macrophage OXPHOS regulation by HIV-1 Vpr and cocaine. 14th International Symposium on Neurovirology, Oct 25-28, 2016, Toronto, Ontario, Canada.
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EVs released from Tat-treated microglia inhibit EAAT2 expression in astrocytes. Third Annual Extracellular Vesicles and Infections meeting" May 31- June 1, 2019, Bolger Center, Potomac, MD.
