B.S., Biological Sciences, Colorado State University, Fort Collins Colorado
PhD, Cellular and Molecular Pathology, University of Wisconsin-Madison, Madison, Wisconsin
- Elite control of HIV and SIV infection
- Identification of latently infected cells
- Mechanisms of protection from pathogenic SIV provided by live attenuated SIV vaccines
- Zika infection of nonhuman primates
My lab studies the immuno-virology of viral infections, particularly in nonhuman primate models of human pathogens. Our work focuses primarily on simian immunodeficiency virus (SIV) infection of rhesus macaques but recently we have begun to study other viruses. We study the importance of epitope-specific T cells in viral control and pathogenesis. We also use deep sequencing to study how SIV evolves to escape T cell responses in vivo. Finally, we study unique events in viral transcription and translation and how these events produce novel targets for the adaptive immune response. All of our efforts are geared towards contributing to the development of vaccines to prevent viral infections.
View Dr. Manness's publications on PubMed.