MS, Immunology, Chinese Academy of Science, China; PhD, Immunology, Fudan University, Shanghai, China
Dr. Huanbin Xu has several years of specialized postdoctoral training in immunology and pathology at both Harvard University and Tulane University medical schools, and is now an Assistant Professor (tenure-track) in the Department of Pathology and Laboratory Medicine at the Tulane University School of Medicine. His major research interests are discovering the follicular T helper cells, germinal center reaction, viral reservoir establishment and their epigenetic regulation during HIV infection, deciphering the effects of maternal HIV infection and antiretroviral therapy on neonatal immune development, and exploring the cure strategy with latent-reversing agents and gene-editing technology for viral reservoir eradication in AIDS therapy.
He collaborates with other investigators and has published on several key topics in adaptive and innate immunity to SIV infection which have been featured in the Journal of Immunology (2010) and Mucosal Immunology (2012). Dr. Xu has also recently published on the innate lymphoid cells and viral reservoir establishment during SIV infection in key journals (FASEB J, 2012, 2015; J Leukoc Biol, 2013; J AIDS Clin Res, 2014; Front Immunol, 2014; J Immunol, 2010, 2015; J Virol, 2015 and Cell Host Microbe, 2016; EBioMedicine, 2017.) Most recently he has been studying abnormal metabolism in mycobacterial tuberculosis infection and HIV-associated neurodegenerative disorders. He has extensive expertise in immunology, virology and molecular biology.
Wang X, Russell-Lodrigue KE, Ratterree MS, Veazey RS and Xu H. Chemokine receptor CCR5 correlates with functional CD8+ T cells in SIV-infected macaques and the potential effects of maraviroc on T-cell activation. 2019. FASEB J. Epub ahead. PMID: 31034775
Xu H, Ziani, Shao JS, Doyle-Meyers LA, Russell-Lodrigue KE, Ratterree M, Veazey RS and Wang X. Impaired development and expansion of germinal center follicular T helper cells in SIV-infected neonatal macaques. J Immunol. 2018. 201(7): 1994-2003. PMID: 30104244
Wang X and Xu H. Potential epigenetic regulation in the germinal center reaction of lymphoid tissues in HIV/SIV infection. Front Immunol. 2018; 9: 159. PMID: 29449847
Xu H, Andersson AM, Ragonnaud E, Boilesen D, Tolver A, Holbech Jensen BA, Blanchard JL, Nicosia A, Folgori A, Colloca S, Cortese R, Thomsen AR, Christensen JP, Veazey RS, Holst PJ. Heterologous viral vectored vaccine targeting SIV accessory antigens strongly inhibits early viral replication and prevents immune hyperactivation. EBioMedicine. 2017. 18: 204-215. PMID: 28585307
Stieh DJ, Matias E, Xu H, Fought AJ, Blanchard JL, Marx PA, Veazey RS and Hope TJ. Th17 cells are preferentially infected very early after vaginal transmission of SIV in Macaques. Cell Host Microbe. 2016 19(4): 529-540. PMID: 27078070.
View Dr. Xu's publications on PubMed.
Outstanding Achievement and Commitment to Excellence In Total Competitive Research funding, Tulane University School of Medicine, 2015.